Assign an object reference.
Syntax
Set variable = object
The variable name, can be anything but typically will start with obj to indicate it is a programmable object with properties and methods.
Methods can be run against the object variable using the syntax objSomething.methodName
Properties can be accessed by assigning a variable: varValue = objSomething.propertyX
Unless you are using ADO objects that have to be explicitly cleaned up in the right order before they go out of scope, it is not necessary to assign object to nothing at the end of your scripts
Example
Set objWshController = WScript.CreateObject("WshController")
“We can make good tests run fast but we can't make fast tests be good” - Ryan Tomayko
Related:
Dim - Declare a new variable or array variable
VB Script Constants and Variables
Set Objects To Nothing? - Eric Lippert